反应详情

2-O-Acetyl-3-O-benzyl-1-O-(6',6'-dimethoxyhexyl)-sn-glycerol (369 mg, 1.0 mmol) was hydrogenated in THF (10 ml) over Palladium/carbon (14 mg, 10%) until the uptake of hydrogen ceased (approx. 2.5 hr.). The solution was filtered through celite, and the filtrate was evaporated to yield a colourless oil (278 mg, 100%) which was used immediately. 1H N.M.R.δ: 5.04,q,l,J 5.0 Hz,H2; 4.40,t,l,J 5.7 Hz, --CH(OMe)2 ; 3.84, d,2,J 5.0 Hz, H3; 3.65, d,2J 5.2 Hz, OCH2 --; 3.56-3.44 m 2 H1; 3.35 s 6 OCH3 ; 2.5,s(b),1,OH; 2.14,s,3, COCH3 ; 1.7-1.3,m,8, --CH2 --.

1. custom(approx. 2.5 hr.)
2. filtrationThe solution was filtered through celite
3. customthe filtrate was evaporated