Hydrogen Bromide → HCID 12557096, compound

HRID 346099Notes

Reaction equation

HRID 346099 reaction equation
O[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)([CH2:5]3)[CH2:3]1)[CH2:9]2.[BrH:18]>C(O)(=O)C.O>[Br:18][C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)([CH2:5]3)[CH2:3]1)[CH2:9]2

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 598893HCID 598893, compound

Product 1

HCID 12557096HCID 12557096, compoundYield 68%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Stir 0.03 mol of 3-phenyl adamantanol (II) with 100 ml of 40% HBr in glacial acetic acid for 20 min at 60° C. and 30 min at room temperature. Subsequently, dilute the reaction mixture with water and extract with ether. Wash the combined organic extracts with sodium chloride solution, dry with magnesium sulfate, filter and evaporate to dryness under vacuum. Recrystallize the residue from methanol. (Yield: 68%).

Workup

  1. custom30 min
  2. customat room temperature
  3. extractionextract with ether
  4. washWash the combined organic extracts with sodium chloride solution
  5. dry with materialdry with magnesium sulfate
  6. filtrationfilter
  7. customevaporate to dryness under vacuum
  8. customRecrystallize the residue from methanol

Sources & evidence

ORD record
ord-bc891da1f27c4186bb9007e599802774
Source dataset
uspto-grants-1991_10
Patent number
US05061703

Reaction notes

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