反应详情

A solution of 4-(prop-2-yn-1-yl)-2,3,5,6-tetrafluorobenzyl alcohol (0.1 g) copper (II) chloride (1.3 g), and lithium chloride (0.62 g) in dry acetonitrile (23 cm3) was heated at the reflux temperature for 40 hours. The resulting dark solution was poured into dilute hydrochloric acid, and extracted into ethyl acetate. The organic phase was washed with more dilute hydrochloride acid, dried, and the solvent evaporated under reduced pressure to give Z-4-(2,3-dichloroprop-2-en-1-yl)-2,3,5,6-tetrafluorobenzyl alcohol (0.1 g) as an orange oil.

1. extractionextracted into ethyl acetate
2. washThe organic phase was washed with more dilute hydrochloride acid
3. customdried
4. customthe solvent evaporated under reduced pressure