反应详情

Mix 0.5 mol of 1,3-dimethyl adamantane with a ten times excess of bromine (5 mol). Slowly heat and stir for 4 hrs under reflux. Subsequently, allow to cool and pour onto ice water. Decompose the excess bromine with sodium sulfite until discoloration of the aqueous solution. Then extract with ether, wash the combined organic phases with sodium bicarbonate solution, dry with magnesium sulfate, filter and evaporate to dryness under vacuum. Recrystallize the residue from methanol. (Yield: 83%).

1. temperatureSlowly heat
2. temperatureunder reflux
3. temperatureto cool
4. additionpour onto ice water
5. extractionThen extract with ether
6. washwash the combined organic phases with sodium bicarbonate solution
7. dry with materialdry with magnesium sulfate
8. filtrationfilter
9. customevaporate to dryness under vacuum
10. customRecrystallize the residue from methanol