Hydrogen Bromide → HCID 15068770, compound

HRID 346107Notes

Reaction equation

HRID 346107 reaction equation
[CH2:1]([C:3]12[CH2:12][C:7]3([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH2:8][CH:9]([CH2:11][C:5](O)([CH2:6]3)[CH2:4]1)[CH2:10]2)[CH3:2].[BrH:20]>C(O)(=O)C.O>[Br:20][C:5]12[CH2:6][C:7]3([C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH2:8][CH:9]([CH2:10][C:3]([CH2:1][CH3:2])([CH2:12]3)[CH2:4]1)[CH2:11]2

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 15068769HCID 15068769, compound

Product 1

HCID 15068770HCID 15068770, compoundYield 68%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Stir 0.03 mol of 1-ethyl-3-hydroxy-5-phenyl adamantane (III) with 100 ml of 40% HBr in glacial acetic acid for 20 min at 60° C. and for 30 min at room temperature. Subsequently dilute the reaction mixture with water and extract with ether. Wash the combined organic extracts with sodium chloride solution, dry with magnesium sulfate, filter and evaporate to dryness under vacuum. Recrystallize the residue from methanol. (Yield: 68%).

Workup

  1. extractionextract with ether
  2. washWash the combined organic extracts with sodium chloride solution
  3. dry with materialdry with magnesium sulfate
  4. filtrationfilter
  5. customevaporate to dryness under vacuum
  6. customRecrystallize the residue from methanol

Sources & evidence

ORD record
ord-aa2793cc6ca64d9a800a5516695f2915
Source dataset
uspto-grants-1991_10
Patent number
US05061703

Reaction notes

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