Hydrochloric Acid → HCID 135544558, compound

HRID 346108Notes

Reaction equation

HRID 346108 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[O:26])[C:5]([N+:23]([O-:25])=[O:24])=[C:6]([C:8]([C:21]#[N:22])([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)C(OCC)=O)[N:7]=1.Cl>[OH-].[Na+]>[NH2:1][C:2]1[NH:3][C:4](=[O:26])[C:5]([N+:23]([O-:25])=[O:24])=[C:6]([CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:21]#[N:22])[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136364601HCID 136364601, compound

Product 1

HCID 135544558HCID 135544558, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 2-Amino-α-cyano-1,6-dihydro-5-nitro-α-(phenylmethyl)-6-oxo-4-pyrimidineacetic acid, ethyl ester as prepared above (2.0 g) in 1N NaOH (100 mL) is stirred at room temperature for 1 h and is acidified with 4N HCl (30 mL). The precipitate is collected by filtration and dried under vacuum to give 2-Amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile (600 mg, 36%). ##STR13##

Workup

  1. filtrationThe precipitate is collected by filtration
  2. customdried under vacuum

Sources & evidence

ORD record
ord-48228dbb648443e7b112299e3f94aa6c
Source dataset
uspto-grants-1991_10
Patent number
US05061707

Reaction notes

Loading…