Sulfuric Acid → HCID 19990493, compound

HRID 346121Notes

Reaction equation

HRID 346121 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[CH:12][N:11]=2.S(=O)(=O)(O)O>O.C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([N:16]=1)=[CH:14][C:13]([C:8](=[O:9])[CH2:3][CH2:2][CH3:7])=[CH:12][N:11]=2

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 3040488Oxazolo(5,4-b)pyridine, 2-(2-fluorophenyl)-

Product 1

HCID 19990493HCID 19990493, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Using the procedure described in Example 1, but replacing 2-phenyloxazolo[4,5-b]pyridine by 2-(2-fluorophenyl)oxazolo[5,4-b]pyridine (J. Med. Chem. 1978, 21, 11, 1158+) and using 8.4 ml of concentrated sulfuric acid in 16.8 ml of water and 16.8 ml of acetic acid, and after purification on a column of silica (40 to 63μ; 70-230 mesh; eluent: ethyl acetate/toluene, 1:9), the product of the title is obtained.

Workup

  1. customafter purification on a column of silica (40 to 63μ; 70-230 mesh; eluent: ethyl acetate/toluene, 1:9)
  2. customthe product of the title is obtained

Sources & evidence

ORD record
ord-b3f8e3a548fb4fb5bc127e991fc64051
Source dataset
uspto-grants-1991_10
Patent number
US05061713

Reaction notes

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