反应详情

To a solution of 2.4 g (8.1 mmol) 5-chloro-2-ethoxalylaminobenzotrifluoride in 13 ml 95-97% sulfuric acid a solution of 12 ml 100% nitric acid in 24 ml 95-97% sulfuric acid was added dropwise at 0°-5° C. Stirring was continued at 25° C. for 20 min. The reaction mixture was poured into 100 ml ice-water to give an oil. Extraction with dichloromethane gave 2.1 g (76%) of 5-chloro-2-ethoxalylamino-3-nitrobenzotrifluoride as crystals. M.p. 100°-101° C.

1. customto give an oil
2. extractionExtraction with dichloromethane