HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 5-Chloro-2-ethoxalylamino-3-nitrobenzotrifluoride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Ethyl 2-[4-chloro-2-(trifluoromethyl)anilino]-2-oxoacetate | HCID 4550962 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 5-Chloro-2-ethoxalylamino-3-nitrobenzotrifluoride | HCID 19980305 | 76% |
Reaction Steps
To a solution of 2.4 g (8.1 mmol) 5-chloro-2-ethoxalylaminobenzotrifluoride in 13 ml 95-97% sulfuric acid a solution of 12 ml 100% nitric acid in 24 ml 95-97% sulfuric acid was added dropwise at 0°-5° C. Stirring was continued at 25° C. for 20 min. The reaction mixture was poured into 100 ml ice-water to give an oil. Extraction with dichloromethane gave 2.1 g (76%) of 5-chloro-2-ethoxalylamino-3-nitrobenzotrifluoride as crystals. M.p. 100°-101° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05061706 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-c9c2ccc2d5cb402cb46c594424500cb2 |
| Source note | uspto-grants-1991_10 |