反应详情

温度

135 °C

To a stirred solution of 22.5 g (0.092 mole) of 4-(3-chloropropoxy)benzoic acid ethyl ester in 150 mL of dimethylformamide was added 17.6 g (0.093 mole) of potassium phthalimide (98%, Aldrich) and the mixture was heated (135° C.) under a nitrogen atmosphere for 8 hr. The solvent was evaporated under reduced pressure to leave a semi-solid residue. The residue was triturated with 100 mL of water and the resulting solid was collected by filtration. The solid was recrystallized from isopropyl alcohol to yield 18.2 g (55%) of title compound as an off-white solid, mp 106°-108° C.

1. customThe solvent was evaporated under reduced pressure
2. customto leave a semi-solid residue
3. customThe residue was triturated with 100 mL of water
4. filtrationthe resulting solid was collected by filtration
5. customThe solid was recrystallized from isopropyl alcohol