反应详情

To a stirred solution of 76.6 g (0.5 mole) of 5-aminosalicyclic acid in 252.0 g (8 mole) of methanol was added 150.0 g (1.06 mole) of borontrifluoride etherate (Aldrich) and the mixture was heated at reflux overnight. The reaction mixture was treated with 150 mL of water and filtered. The filtrate pH was adjusted to 8.4 with sodium bicarbonate, and the resulting solid was collected by filtration and air dried to give 43.0 g (51%) of crude title compound as a solid. A sample was dissolved in methylene chloride, treated with charcoal and filtered. The filtrate was concentrated under reduced pressure to give a solid. The solid was recrystallized from methylene chloride-petroleum ether (30°-60° C.) to give title compound as golden-brown needles, mp 95°-98° C.

1. temperaturethe mixture was heated
2. temperatureat reflux overnight
3. filtrationfiltered
4. filtrationthe resulting solid was collected by filtration and air
5. customdried
6. customto give 43.0 g (51%) of crude title compound as a solid
7. filtrationfiltered
8. concentrationThe filtrate was concentrated under reduced pressure
9. customto give a solid
10. customThe solid was recrystallized from methylene chloride-petroleum ether (30°-60° C.)