Hydrochloric Acid → HCID 14726536, compound

HRID 346284Notes

Reaction equation

HRID 346284 reaction equation
[NH2:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]2([CH3:18])[CH3:17])=[O:4].[ClH:19]>CO.[Pd]>[ClH:19].[NH2:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]2([CH3:18])[CH3:17])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 14726535HCID 14726535, compound

Product 1

HCID 14726536HCID 14726536, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

16.2 g (63.5 millimoles) of 6-aminoacetyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene in 250 ml of methanol and 59 ml of 2N hydrochloric acid were hydrogenated with 2.9 g of 10% strength palladium on active carbon at room temperature and under atmospheric pressure. The reaction mixture was filtered over Celite and the filtrate was evaporated down. The residue was stirrred with ether and a few drops of methanol and the precipitated crystals were filtered off under suction. After drying, 5.8 g of 6-aminoacetyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene hydrochloride remained. The structure was determined by H-NMR spectroscopy.

Workup

  1. filtrationThe reaction mixture was filtered over Celite
  2. customthe filtrate was evaporated down
  3. filtrationthe precipitated crystals were filtered off under suction
  4. customAfter drying

Sources & evidence

ORD record
ord-f2e78a6079524b1bb7825fdd1824f19d
Source dataset
uspto-grants-1991_10
Patent number
US05061705

Reaction notes

Loading…