HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-[2-Amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | tert-Butyl isocyanate | HCID 62412 | — |
| Reactant | 2,7-Diamino-6-o-tolyl-pyrido[2,3-d]pyrimidine | HCID 21850031 | — |
| Solvent | Methane | HCID 297 | — |
| Product | 1-[2-Amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea | HCID 5329118 | — |
Reaction Steps
The title compound was prepared from 6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 90 and tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with CHCl3 :EtOAc (1:1) afford the pure product; mp 195°-197° C., CIMS (1% ammonia in methane): m/z (relative intensity) 351 (MH+ +1, 55), 352 (MH+ +2, 12), 84 (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05733913 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-402f050ecfe844a4a9c4948e241fc170 |
| Source note | uspto-grants-1998_03 |