HRID34637

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID240

Benzaldehyde

C7H6O

HCID7725

4-Methylbenzaldehyde

C8H8O

结构：NC1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2)C1

HCID13500657

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(C=NC2CCN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3)C2)cc1

HCID14230012

未命名化合物

PROCEDURE

实验过程

In the described fashion of Example 1 replacing benzaldehyde with p-methylbenzaldehyde and using the acid (1) (R=ethyl) described in example 13 one obtains 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-p-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3) (R=ethyl-Z=p-methylphenyl).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1bb6a1e52f5b4b2dad9918f735277401
来源数据集: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04762845
来源说明: uspto-grants-1988_08

反应 SMILES

C(=O)C1C=CC=CC=1.[CH3:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[C:34]3[C:29](=[CH:30][C:31]([F:41])=[C:32]([N:35]4[CH2:39][CH2:38][CH:37]([NH2:40])[CH2:36]4)[CH:33]=3)[C:28](=[O:42])[C:27]([C:43]([OH:45])=[O:44])=[CH:26]2)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[C:34]3[C:29](=[CH:30][C:31]([F:41])=[C:32]([N:35]4[CH2:39][CH2:38][CH:37]([N:40]=[CH:9][C:10]5[CH:17]=[CH:16][C:13]([CH3:14])=[CH:12][CH:11]=5)[CH2:36]4)[CH:33]=3)[C:28](=[O:42])[C:27]([C:43]([OH:45])=[O:44])=[CH:26]2)=[CH:21][CH:20]=1