Sodium Iodide → HCID 131717063, compound

HRID 346395Notes

Reaction equation

HRID 346395 reaction equation
Cl[CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@H:26]([NH:27][C:28](=[O:58])[C:29](=[N:55][O:56][CH3:57])[C:30]3[N:31]=[C:32]([NH:35]C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[S:33][CH:34]=3)[C:25](=[O:59])[N:7]2[C:8]=1[C:9]([O:11]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:10].[I-].[Na+:61].[OH:62][C:63]1[CH:68]=[CH:67][C:66]([C:69]2[O:73][C:72]([SH:74])=[N:71][CH:70]=2)=[CH:65][CH:64]=1>>[NH2:35][C:32]1[S:33][CH:34]=[C:30]([C:29](=[N:55][O:56][CH3:57])[C:28]([NH:27][C@@H:26]2[C:25](=[O:59])[N:7]3[C:8]([C:9]([O-:11])=[O:10])=[C:3]([CH2:2][S:74][C:72]4[O:73][C:69]([C:66]5[CH:65]=[CH:64][C:63]([OH:62])=[CH:68][CH:67]=5)=[CH:70][N:71]=4)[CH2:4][S:5][C@H:6]23)=[O:58])[N:31]=1.[Na+:61]

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 131717062HCID 131717062, compoundHCID 178515882HCID 178515882, compound

Product 1

HCID 131717063HCID 131717063, compoundYield 9%

Procedure

The same operation as in EXAMPLE 65 was conducted by using 840 mg (1.0 mmol) of benzhydryl 3-chloromethyl-7β-[2-methoxyimino-2-( 2-tritylaminothiazol-4-yl)acetamido]-3-cephem-4-carboxylate (syn-isomer), 225 mg (1.5 mmol) of sodium iodide and 193 mg (1.0 mmol) of 5-(4-hydroxyphenyl)-2mercaptooxazole, whereby 55 mg (yield: 9.0%) of the above identified compound was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-cd5f14425e1447cf87c78a00662a0d9e
Source dataset
uspto-grants-1991_10
Patent number
US05061794

Reaction notes

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