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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 346415Generated: October 25, 2026

Acryloyl chloride → N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)acrylamide

https://huagongshe.com/reaction/346415

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcryloyl chlorideHCID 13140—
Reactant4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-aminoquinazolineHCID 11544325—
SolventTetrahydrofuranHCID 8028—
ProductN-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)acrylamideHCID 10362209—

Reaction Steps

Acryloyl chloride was reacted with 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline in THF, at 0° C. The final product was obtained in quantitative yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07172749B2
Source datasetuspto-grants-2007_02
ORD IDord-417509d1b40c4e22819fd3234a86a41e
Source noteuspto-grants-2007_02