Acryloyl chloride → N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)acrylamide

HRID 346415Notes

Reaction equation

HRID 346415 reaction equation
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].[Cl:6][C:7]1[CH:8]=[C:9]([NH:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([NH2:26])[CH:24]=3)[N:19]=[CH:18][N:17]=2)[C:10]([F:14])=[CH:11][C:12]=1[Cl:13]>C1COCC1>[Cl:6][C:7]1[CH:8]=[C:9]([NH:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([NH:26][C:1](=[O:4])[CH:2]=[CH2:3])[CH:24]=3)[N:19]=[CH:18][N:17]=2)[C:10]([F:14])=[CH:11][C:12]=1[Cl:13]

Participants

4

Reactant 2

HCID 13140Acryloyl chlorideHCID 115443254-[(3,4-Dichloro-6-fluorophenyl)amino]-6-aminoquinazoline

Product 1

HCID 10362209N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)acrylamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Acryloyl chloride was reacted with 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline in THF, at 0° C. The final product was obtained in quantitative yield.

Sources & evidence

ORD record
ord-417509d1b40c4e22819fd3234a86a41e
Source dataset
uspto-grants-2007_02
Patent number
US07172749B2

Reaction notes

Loading…