Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 346416Generated: October 26, 2026

4,5-Dichloro-2-fluoroaniline → 4-[(3,4-Dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline

https://huagongshe.com/reaction/346416

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,5-Dichloro-2-fluoroanilineHCID 223091—
Reactant4-Chloro-7-fluoro-6-nitroquinazolineHCID 10609358—
SolventIsopropanolHCID 3776—
Product4-[(3,4-Dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazolineHCID 1117618578%

Reaction Steps

3,4-Dichloro-6-fluoroaniline (1 equivalent) was reacted with 4-chloro-7-fluoro-6-nitroquinazoline (3.5 equivalents), in iso-propylalcohol. After filtration, 4-[(3,4-dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline was obtained in 78% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07172749B2
Source datasetuspto-grants-2007_02
ORD IDord-1042ad855505453485b72441af00c3ae
Source noteuspto-grants-2007_02