Dimethylamine → N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide

HRID 346423Notes

Reaction equation

HRID 346423 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH2:19])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.Br/C(=C\C)/C(O)=O.CNC.IC1C=C(NC2C3C(=CC=C(N[C:49](=[O:56])[CH:50]=[CH:51][CH2:52][N:53]([CH3:55])[CH3:54])C=3)N=CN=2)C=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:49](=[O:56])[CH:50]=[CH:51][CH2:52][N:53]([CH3:55])[CH3:54])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 4

HCID 674DimethylamineHCID 53129522-Bromo-2-Butenoic AcidHCID 5328042N4-(3-Bromophenyl)quinazoline-4,6-diamineHCID 68562749N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(dimethylamino)-2-butenamide

Product 1

HCID 49826478N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide

Procedure

4-[(3-bromophenyl)amino]-6-aminoquinazoline is reacted with bromocrotonic acid and dimethylamine, as is described hereinabove in Compound 5, to give N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide.

Sources & evidence

ORD record
ord-3894a2dacea5405f82545427bd925ca1
Source dataset
uspto-grants-2007_02
Patent number
US07172749B2

Reaction notes

Loading…