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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 346423Generated: October 30, 2026

Dimethylamine → N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide

https://huagongshe.com/reaction/346423

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamineHCID 674—
Reactant2-Bromo-2-Butenoic AcidHCID 5312952—
ReactantN4-(3-Bromophenyl)quinazoline-4,6-diamineHCID 5328042—
ReactantN-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(dimethylamino)-2-butenamideHCID 68562749—
ProductN-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamideHCID 49826478—

Reaction Steps

4-[(3-bromophenyl)amino]-6-aminoquinazoline is reacted with bromocrotonic acid and dimethylamine, as is described hereinabove in Compound 5, to give N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07172749B2
Source datasetuspto-grants-2007_02
ORD IDord-3894a2dacea5405f82545427bd925ca1
Source noteuspto-grants-2007_02