1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → Boc-prolylproline methyl ester

Participants

Reaction Steps

2.15 g (10 mmol) BOC-L-proline and 1.66 g (10 mmol) proline methyl ester HCl salt were coupled according to procedure A. Yield of crude product 2.83 g. The product was purified with a silica column using 5% methanol in ethyl acetate as eluent. Yield 2.40 g (7.4 mmol, 74%)

Provenance & Evidence