反应详情

To a warm solution of 4.61 g (28.60 mmol) of 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one (Example 41) in 50 ml of 48% hydrobromic acid is added dropwise a solution of 5.00 g (31.28 mmol) of bromine in 10 ml of 48% hydrobromic acid. The solution is stirred at room temperature for 2 hours and then concentrated to an orange oil. Crystallization in 95% ethanol affords 6.93 g (75.5%) of 6-bromo-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one, hydrobromide as a white solid; mp 193°-195° C.

1. concentrationconcentrated to an orange oil
2. customCrystallization in 95% ethanol