Sodium Hydroxide → 4-Thiazolecarboxylicacid,5-(ethylthio)-

HRID 34665Notes

Reaction equation

HRID 34665 reaction equation
[CH2:1]([S:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]([O:11]C)=[O:10])[CH3:2].[OH-].[Na+]>CO.O>[C:9]([C:5]1[N:6]=[CH:7][S:8][C:4]=1[S:3][CH2:1][CH3:2])([OH:11])=[O:10]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 21298284Methyl 5-ethylthio-1,3-thiazole-4-carboxylate

Product 1

HCID 136879364-Thiazolecarboxylicacid,5-(ethylthio)-Yield 84.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

6 g of methyl 5-ethylthio-1,3-thiazole-4-carboxylate were dissolved in 100 ml of methanol and heated with 1.2 g of NaOH in 10 ml of water under reflux for about 1 h. After the solvent had been removed in a rotary evaporator, the solids were removed by filtration, and the filtrate was acidified with 2N HCl solution. After drying, 4.7 g of the title compound, of melting point 158°-9° C., were obtained.

Workup

  1. temperatureunder reflux for about 1 h
  2. customAfter the solvent had been removed in a rotary evaporator
  3. customthe solids were removed by filtration
  4. customAfter drying

Sources & evidence

ORD record
ord-39bbea6fbf0a43e38301504dfc6c5430
Source dataset
uspto-grants-1988_08
Patent number
US04762848

Reaction notes

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