Sodium Hydroxide → 4-Thiazolecarboxylicacid,5-(ethylthio)-

Participants

Reaction Steps

6 g of methyl 5-ethylthio-1,3-thiazole-4-carboxylate were dissolved in 100 ml of methanol and heated with 1.2 g of NaOH in 10 ml of water under reflux for about 1 h. After the solvent had been removed in a rotary evaporator, the solids were removed by filtration, and the filtrate was acidified with 2N HCl solution. After drying, 4.7 g of the title compound, of melting point 158°-9° C., were obtained.

Provenance & Evidence