1-(4-Pyridyl)piperazine → 1-[4-(2-Naphthylsulphonyl)benzoyl]-4-(4-pyridyl)piperazine

HRID 346664Notes

Reaction equation

HRID 346664 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23]([C:26]1[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=1)(=[O:25])=[O:24]>>[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23]([C:26]1[CH:34]=[CH:33][C:29]([C:30]([N:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)=[O:31])=[CH:28][CH:27]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 183570674-(2-Naphthylsulphonyl)benzoic acid

Product 1

HCID 179157181-[4-(2-Naphthylsulphonyl)benzoyl]-4-(4-pyridyl)piperazineYield 32%

Procedure

Using an analogous procedure to that described in Example 1, N-(4-pyridyl)piperazine was reacted with 4-(2-naphthylsulphonyl)benzoic acid to give 1-[4-(2-naphthylsulphonyl)benzoyl]-4-(4-pyridyl)piperazine in 32% yield;

Sources & evidence

ORD record
ord-70192ce45baa4ddab6ae27541afaf4c6
Source dataset
uspto-grants-2007_02
Patent number
US07173025B1

Reaction notes

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