4-Toluenesulfonyl chloride → HCID 131726228, compound

HRID 346666Notes

Reaction equation

HRID 346666 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([O:13][C:14]3[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[C:21]1([CH3:31])[CH:26]=[CH:25][C:24]([S:27]([Cl:30])(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[ClH:30].[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([O:13][C:14]3[CH:20]=[CH:19][C:17]([NH:18][S:27]([C:24]4[CH:25]=[CH:26][C:21]([CH3:31])=[CH:22][CH:23]=4)(=[O:29])=[O:28])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 18357062HCID 18357062, compound

Product 1

HCID 131726228HCID 131726228, compoundYield 54%

Procedure

Using an analogous procedure to that described in Example 4, 4-[1-(4-pyridyl)piperidin-4-yloxy]aniline was reacted with 4-toluenesulphonyl chloride to give N-{4-[1-(4-pyridyl)piperidin-4-yloxy]phenyl}-4-toluenesulphonamide, hydrochloride salt, in 54% yield, m.p. 270-272° C.;

Sources & evidence

ORD record
ord-a739cdb553fe4e229ecd8ac9f8217cf9
Source dataset
uspto-grants-2007_02
Patent number
US07173025B1

Reaction notes

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