Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate → HCID 15093271, compound

HRID 34672Notes

Reaction equation

HRID 34672 reaction equation
[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([O:15]C(C)(C)C)=[O:14])([O:3][CH3:4])=[O:2]>FC(F)(F)C(O)=O>[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([OH:15])=[O:14])([O:3][CH3:4])=[O:2]

Participants

3

Reactant 1

HCID 15093267Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate

Product 1

HCID 15093271HCID 15093271, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

7.8 g of tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate are stirred in a mixture of 100 ml of trifluoroacetic acid and 100 ml of methylene ohloride at room temperature for 30 min. The solvent is removed in vacuo, and the residue is extracted by stirring with 100 ml of ether/petroleum ether (50°-70° C.) 1/1. After filtration and drying, 6.2 g of melting point 112°-116° C. are obtained, melting point 120°-121° C. after recrystallization from ethyl acetate.

Workup

  1. customThe solvent is removed in vacuo
  2. extractionthe residue is extracted
  3. filtrationAfter filtration
  4. customdrying
  5. custom6.2 g of melting point 112°-116° C. are obtained
  6. custommelting point 120°-121° C. after recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-e56279be3e36461cb3c5171b1f57e0d3
Source dataset
uspto-grants-1988_08
Patent number
US04762848

Reaction notes

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