4-Toluenesulfonyl chloride → 4-Methyl-N-[2-[(phenylsulfonyl)amino]-4-(1-piperazinyl)phenyl]benzenesulfonamide

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Reaction Steps

4-Methyl-N-[2-[(phenylsulfonyl)amino]-4-(1-piperazinyl)phenyl]benzenesulfonamide was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-piperazinyl)-phenyl}benzenesulfonamide and p-toluenesulfonylchloride (46 mg, 0.239 mmol) according to general method 3 to give 70 mg of a purple solid. MS (posES-FIA) m/z=Found: 487.2; Calcd: 487.14; 1H-NMR δ 7.73–7.45 (m, 7H), 7.26 (d, 2H), 6.74 (s, 1H), 6.62–6.60 (m, 2H), 3.69 (app t, 2H), 3.39 (app t, 2H), 3.29–3.74 (m, 4H), 2.38 (s, 3H).

Provenance & Evidence