Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl-2-(3-(4-methoxybenzyloxycarbonyl)propylthio)-4-methyl-1,3-thiazol-5-ylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Methoxybenzyl 4-chlorobutyrate | HCID 12425680 | — |
| 반응물 | HCID 178499653 | HCID 178499653 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Methyl-2-(3-(4-methoxybenzyloxycarbonyl)propylthio)-4-methyl-1,3-thiazol-5-ylacetate | HCID 131715689 | — |
반응 단계
10.2 g of methyl 2-mercapto-4-methyl-1,3-thiazol-5-yl-acetate are dissolved in 200 ml of acetone, and the solution is vigorously stirred with 12.1 g of 4-methoxybenzyl 4-chlorobutyrate in the presence of 13.0 g of powdered, dry potassium carbonate (potash) while maintaining the ambient temperature. After filtration, acetone is removed in vacuo, and the residue is purified by column chromatography (SiO2, ethyl acetate/cyclohexane 1:1). ##STR8##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762848 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-a514ed01ea4c4cae9f6811e857b957ec |
| 출처 메모 | uspto-grants-1988_08 |