反应详情

10.2 g of methyl 2-mercapto-4-methyl-1,3-thiazol-5-yl-acetate are dissolved in 200 ml of acetone, and the solution is vigorously stirred with 12.1 g of 4-methoxybenzyl 4-chlorobutyrate in the presence of 13.0 g of powdered, dry potassium carbonate (potash) while maintaining the ambient temperature. After filtration, acetone is removed in vacuo, and the residue is purified by column chromatography (SiO2, ethyl acetate/cyclohexane 1:1). ##STR8##

1. filtrationAfter filtration, acetone
2. customis removed in vacuo
3. customthe residue is purified by column chromatography (SiO2, ethyl acetate/cyclohexane 1:1)