Hydrochloric Acid → HCID 178524783, Verbindung

HRID 34677Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34677
[OH-].[Na+].C[O:4][C:5]([C:7]1[N:11]([CH2:12][C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=2)[C:10]([SH:21])=[N:9][CH:8]=1)=[O:6].Cl>O>[F:20][C:15]1[CH:14]=[C:13]([CH:18]=[C:17]([F:19])[CH:16]=1)[CH2:12][N:11]1[C:7]([C:5]([OH:6])=[O:4])=[CH:8][N:9]=[C:10]1[SH:21]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178498871HCID 178498871, Verbindung

Produkt 1

HCID 178524783HCID 178524783, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of sodium hydroxide (2.70 g, 0.674 mole) in water (110 ml) was added to 1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxylic acid methyl ester prepared as above (6.39 g, 0.0225 mole) and the resulting solution was stirred for 2 hours. The solution was cooled in ice, acidified to pH 2 with 3N hydrochloric acid, and the product was filtered and dried. The product was recrystallized from ethanol-water and dried to give 1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxylic acid, m.p.: 240°-241° C. (5.66 g, 93%).

Aufarbeitung

  1. temperatureThe solution was cooled in ice
  2. filtrationthe product was filtered
  3. customdried
  4. customThe product was recrystallized from ethanol-water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-af159b7c839c4077aef0ebb6888a9e8f
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762850

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