反应详情

A suspension of 2.0 g of N-Acetyl-m-benzoyl-D-phenylalanine in 15 ml of 8N hydrochloric acid was heated to 100° in the steam bath for 4 h. The suspension was filtered hot, solid was washed with 8N hydrochloric acid, then water. The filtrate was neutralized with 1N sodium hydroxide and yielded 1.503 g of m-benzoyl-D-phenylalanine after water washing and drying under nitrogen, m.p. 230°-231°, [α]D25 =+3.3±0.8 C=0.90 g/100 ml 1N HCl. Anal.: Calcd. for C16H15NO3 : C, 71.36; H, 5.61; N, 5.20. Found: C, 70.43; H, 5.34; N, 5.37.

1. temperaturewas heated to 100° in the steam bath for 4 h
2. filtrationThe suspension was filtered hot
3. washsolid was washed with 8N hydrochloric acid