HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 346977Generated: October 30, 2026
Phosphorus oxychloride → [2-Chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride
https://huagongshe.com/reaction/346977
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone | HCID 15524330 | — |
| Product | [2-Chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride | HCID 22385762 | 100% |
Reaction Steps
A mixture of 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone (0.127 mol), described in International Patent Specification WO 97/21701, in phosphoryl chloride (125 ml) was stirred and heated at 40° C. for one night, stirred further at 70° C. for one night and evaporated till dryness, yielding (100%) of [2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride (1:1) (intermediate 55).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07173040B2 |
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| Source dataset | uspto-grants-2007_02 |
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| ORD ID | ord-5a2ad0e359c042cf957287ffada229b0 |
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| Source note | uspto-grants-2007_02 |
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