反应详情

温度

80 °C

NaOMe, 30% methanol (300 ml) was added to a mixture of intermediate (55) (0.127 mol) in methanol (285 ml) and the mixture was stirred at 80° C. for one night. The precipitate was filtered off, washed with ethanol and dried. The product (44.8 g, 87%) was taken up in DCM and the layers were separated. The organic layer was dried (MgSO4), filtered off and evaporated till dryness, yielding 32.3 g (62%) of (4-chlorophenyl)[4-(3-chlorophenyl)-2-methoxy-6-quinolinyl]-methanone (intermediate 56).

1. filtrationThe precipitate was filtered off
2. washwashed with ethanol
3. customdried
4. customthe layers were separated
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered off
7. customevaporated till dryness