HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 346978Generated: October 30, 2026
Sodium Methoxide → (4-Chlorophenyl)[4-(3-chlorophenyl)-2-methoxy-6-quinolinyl]methanone
https://huagongshe.com/reaction/346978
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | [2-Chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride | HCID 22385762 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4-Chlorophenyl)[4-(3-chlorophenyl)-2-methoxy-6-quinolinyl]methanone | HCID 21578663 | 62% |
Reaction Steps
NaOMe, 30% methanol (300 ml) was added to a mixture of intermediate (55) (0.127 mol) in methanol (285 ml) and the mixture was stirred at 80° C. for one night. The precipitate was filtered off, washed with ethanol and dried. The product (44.8 g, 87%) was taken up in DCM and the layers were separated. The organic layer was dried (MgSO4), filtered off and evaporated till dryness, yielding 32.3 g (62%) of (4-chlorophenyl)[4-(3-chlorophenyl)-2-methoxy-6-quinolinyl]-methanone (intermediate 56).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07173040B2 |
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| Source dataset | uspto-grants-2007_02 |
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| ORD ID | ord-744b983c6a914cb590063998742017bc |
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| Source note | uspto-grants-2007_02 |
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