Pyrrolidine → HCID 22314142, compound

HRID 347091Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:24]=[CH:23][C:10]2[C:11]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)=[N:12][S:13](=[O:15])(=[O:14])[C:9]=2[CH:8]=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([C:11]2[C:10]3[CH:23]=[CH:24][C:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][N:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)=[CH:8][C:9]=3[S:13](=[O:15])(=[O:14])[N:12]=2)=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 22313958HCID 22313958, compound

Product 1

HCID 22314142HCID 22314142, compound

Procedure

According to the method in example 10, 6-(4-Bromo-butoxy)-3-(4-chloro-phenyl)-benzo[d]isothiazole 1,1-dioxide and Pyrrolidine were converted to yield 3-(4-Chloro-phenyl)-6-(4-pyrrolidin-1-yl-butoxy)-benzo[d]isothiazole 1,1-dioxide, MS: 419 (MH+, 1Cl).

Sources & evidence

ORD record: ord-d4fd9619151a4de29c82cc3a435201cf
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07173043B2

Reaction notes

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