Hydrochloric Acid → 16alpha-Cyano-11beta,21-dihydroxy-3,20-dioxo-1,4-pregnadiene

HRID 34722Notes

Reaction equation

HRID 34722 reaction equation
C([O:4][CH2:5][C:6](=[O:30])[C@@H:7]1[C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C@H:21]([C@@H:22]([OH:26])[CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:27])[CH:17]=[CH:18]2)[CH2:13][CH2:12]3)[CH2:9][C@H:8]1[C:28]#[N:29])(=O)C.Cl>>[C:28]([C@@H:8]1[CH2:9][C@@H:10]2[C@:24]([CH3:25])([CH2:23][C@H:22]([OH:26])[C@H:21]3[C@H:11]2[CH2:12][CH2:13][C:14]2[C@:19]3([CH3:20])[CH:18]=[CH:17][C:16](=[O:27])[CH:15]=2)[C@H:7]1[C:6](=[O:30])[CH2:5][OH:4])#[N:29]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14233403HCID 14233403, compound

Product 1

HCID 1423340516alpha-Cyano-11beta,21-dihydroxy-3,20-dioxo-1,4-pregnadiene

Procedure

The process of claim 7 which additionally comprises reacting (V) with hydrogen chloride to produce (VI) 16α-cyano-11β,21-dihydroxy-3,20-dioxo-1,4-pregnadiene.

Sources & evidence

ORD record
ord-54c597f8caba4635880efa179ab48e7e
Source dataset
uspto-grants-1988_08
Patent number
US04762919

Reaction notes

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