Trifluoroacetic acid → HCID 22314170, compound

HRID 347232Notes

Reaction equation

HRID 347232 reaction equation
C([O:5][C:6](=[O:25])[CH2:7][O:8][C:9]1[CH:24]=[CH:23][C:12]2[C:13]([C:16]3[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=3)=[N:14][S:15][C:11]=2[CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:22][C:19]1[CH:18]=[CH:17][C:16]([C:13]2[C:12]3[CH:23]=[CH:24][C:9]([O:8][CH2:7][C:6]([OH:25])=[O:5])=[CH:10][C:11]=3[S:15][N:14]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69289771[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-acetic acid tert-butyl ester

Product 1

HCID 22314170HCID 22314170, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.89 g (9.3 mmol) [3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-acetic acid tert-butyl ester in 35 ml CH2Cl2 were added 17 ml TFA at 0° C. The solution was stirred at RT for 2 h, concentrated and triturated with ether to yield 3 g (89%) [3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-acetic acid as white solid, MS: 362 (M−H,1Br).

Workup

  1. concentrationconcentrated
  2. customtriturated with ether

Sources & evidence

ORD record
ord-53f31db710d845498be0544b83ecf956
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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