2-Chlorobenzothiazole → 2-(s)-(Benzothiazol-2-ylamino)-3-cyclohexyl-n-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-propionamide
Reaction equation
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:11]1[CH2:16][CH2:15][CH:14]([CH2:17][C@H:18]([NH2:22])[C:19]([OH:21])=O)[CH2:13][CH2:12]1.[F:23][C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[N:29]([CH2:33][CH2:34][NH2:35])[CH2:28][CH2:27]2>>[S:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH:22][C@@H:18]([CH2:17][CH:14]1[CH2:13][CH2:12][CH2:11][CH2:16][CH2:15]1)[C:19]([NH:35][CH2:34][CH2:33][N:29]1[C:30]2[C:26](=[CH:25][C:24]([F:23])=[CH:32][CH:31]=2)[CH2:27][CH2:28]1)=[O:21]Participants
4
Procedure
The title compound was prepared from 2-chlorobenzothiazole, L-cyclohexylalanine and 2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylamine using the procedure analogous to that described in example 2. HPLC-MS calcd. for C26H31FN4OS (M+H+) 467.22. found 467.5.
Sources & evidence
- ORD record
- ord-5850f966bf664b14a23d5ca0bcefb8d6
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07173051B2
Reaction notes
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