反应详情

温度

150 °C

In one example, under nitrogen gas, a stirred mixture of 4-Chloro-1-nitrobenzene (e.g., about 1 g, 6.35 mmol), thioacetic acid (e.g., about 1.93 g, 25.39 mmol), K2CO3 (e.g., about 0.050 g, 0.36 mmol), and dry Triton-X 405 (e.g., about 0.010 g) were heated at about 150° C. The progress of the reaction was monitored by HPLC and GC. After four hours the reaction was cooled to room temperature, and acetone (e.g., about 8 mL) was added and filtered through a sintered glass funnel. Evaporation of the acetone produced about 0.975 g of N-(4-Chloro-phenyl)-acetamide (e.g., about 91%).

1. customdry Triton-X 405 (e.g., about 0.010 g)
2. temperatureAfter four hours the reaction was cooled to room temperature
3. additionacetone (e.g., about 8 mL) was added
4. filtrationfiltered through a sintered glass funnel
5. customEvaporation of the acetone