1-[N-(2-cyanoethyl)tetradecanamido]-5-(4,6-dimethyl-2-pyrimidylamino)-pentane → 1-[N-(3-aminopropyl)tetradecanamido]-5-(4,6-dimethyl-2-pyrimidylamino)pentane

Beteiligte Stoffe

Reaktionsschritte

The nitrile (XIV) (330 mg) was dissolved in 5 ml of 10% conc. NH3 in ethanol to which was added a spatula tip full of 5% Rh on alumina. After 5 hours stirring under 1 atm H2, there was no reaction indicated by tlc or H2 uptake. Additional catalyst (about 2×) and solvent were added and the hydrogenation continued overnight. The catalyst was filtered off and the solvents removed under vacuum to yield the product XV.

Herkunft & Nachweise