反应详情

The nitrile (XIV) (330 mg) was dissolved in 5 ml of 10% conc. NH3 in ethanol to which was added a spatula tip full of 5% Rh on alumina. After 5 hours stirring under 1 atm H2, there was no reaction indicated by tlc or H2 uptake. Additional catalyst (about 2×) and solvent were added and the hydrogenation continued overnight. The catalyst was filtered off and the solvents removed under vacuum to yield the product XV.

1. additionAdditional catalyst (about 2×) and solvent were added
2. waitthe hydrogenation continued overnight
3. filtrationThe catalyst was filtered off
4. customthe solvents removed under vacuum