Pyridine → HCID 10236194, compound

HRID 347609Notes

Reaction equation

HRID 347609 reaction equation
[CH:1]([NH:4][C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[Se:6])([CH3:3])[CH3:2].Cl[CH2:12][C:13](Cl)=[O:14].N1C=CC=CC=1>O1CCCC1>[CH:1]([N:4]1[C:13](=[O:14])[CH2:12][Se:6][C:5]1=[N:7][CH:8]([CH3:10])[CH3:9])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 178458024HCID 178458024, compound

Product 1

HCID 10236194HCID 10236194, compoundYield 101.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.42 g (2.0 mmol) of N,N′-diisopropyl selenourea were dissolved in 20 mL of tetrahydrofuran. 0.08 mL (1.0 mmol) of chloroacetyl chloride were added to the solution, and after stirring well, the mixture was allowed to react at 0 degrees Celsius for one hour. 0.09 mL (1.0 mmol) of pyridine was then added to the reaction mixture, followed by stirring at 0 degrees Celsius for additional 2 hours. The reaction mixture was extracted by an ordinary method, washed with water and dried, and the solvent was distilled off. As a result, 0.25 g of 3-isopropyl-2-isopropylimino-1,3-selenazolidin-4-one were obtained. The purity was 98.7%, and the yield was 100%.

Workup

  1. customto react at 0 degrees Celsius for one hour
  2. stirringby stirring at 0 degrees Celsius for additional 2 hours
  3. extractionThe reaction mixture was extracted by an ordinary method
  4. washwashed with water
  5. customdried
  6. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-861fc3f704e64b7daaf2fca07ca76488
Source dataset
uspto-grants-2007_02
Patent number
US07176164B2

Reaction notes

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