2,3,4,5-tetrahydro-1H-1-benzazepine → HCID 69365105, compound

HRID 347637Notes

Reaction equation

HRID 347637 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][C:11]=1[N+:19]([O-:21])=[O:20])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:22]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[CH2:26][CH2:25][CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([N:22]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:16])=[CH:12][C:11]=1[N+:19]([O-:21])=[O:20])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 5765032,3,4,5-tetrahydro-1H-1-benzazepineHCID 210832664-[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-3-nitrobenzoic acid

Product 1

HCID 69365105HCID 69365105, compound

Procedure

The carboxylic acid from Example B (0.911 g, 3.08 mmol) was reacted with 2,3,4,5-tetrahydro-1H-1-benzazepine (0.453 g, 3.08 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 50:50); yield 0.58 g (43%).

Workup

  1. customThe product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 50:50)

Sources & evidence

ORD record
ord-00cf7f27e33546c5b150427a045b2182
Source dataset
uspto-grants-2007_02
Patent number
US07176195B2

Reaction notes

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