1-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one → 1-Methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

HRID 347645Notes

Reaction equation

HRID 347645 reaction equation
[CH3:1][N:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][CH2:5][CH2:4][C:3]1=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][N:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 210832581-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 119616061-Methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Procedure

1-Methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine from Example 18A (1.7 g, 9.65 mmol) was reduced with lithium aluminium hydride according to the procedure in Example 15A; yield 1.34 g (86%).

Sources & evidence

ORD record
ord-9ac33bcb55ff491595209dfc2f1bc2d1
Source dataset
uspto-grants-2007_02
Patent number
US07176195B2

Reaction notes

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