HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3,4,5-tetrahydro-1,5-benzothiazepine → 5-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1,5-benzothiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3,4,5-tetrahydro-1,5-benzothiazepine | HCID 93963 | — |
| Reactant | 4-Cyano-3-methylbenzoic acid | HCID 10241099 | — |
| Product | 5-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1,5-benzothiazepine | HCID 21083271 | — |
Reaction Steps
The carboxylic acid from Example C (0.27 g; 1.68 mmol) was reacted with 2,3,4,5-tetrahydro-1,5-benzothiazepine (0.28 g, 1.70 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 60:40); yield 0.43 g (84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176195B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-4c0e65abf8874748a2102d6ec57bdfd8 |
| Source note | uspto-grants-2007_02 |