Sodium Hydroxide → HCID 21083632, compound

HRID 347671Notes

Reaction equation

HRID 347671 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:9]([C:11]2[CH:12]=[C:13]([CH2:19][CH2:20][C:21]([O:23]C)=[O:22])[CH:14]=[CH:15][C:16]=2[O:17][CH3:18])=[O:10])[CH:2]=1.[OH-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:9]([C:11]2[CH:12]=[C:13]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:14]=[CH:15][C:16]=2[O:17][CH3:18])=[O:10])[CH:2]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10268326HCID 10268326, compound

Product 1

HCID 21083632HCID 21083632, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Methyl 3-[3-[N-(3-pyridylmethyl)carbamoyl]-4-methoxy-phenyl]propionate (200 mg, 0.609 mmol), 10 mL of methanol and 10 mL of 1 mol/L aqueous solution of sodium hydroxide were mixed and, after stirring for 4 hours at 60° C., the reaction mixture was concentrated under reduced pressure. The residue was neutralized with. 2 mol/L hydrochloric acid under cooling with ice. The precipitates produced were filtered and dried to obtain 90.0 mg (47%) of the title compound as colorless powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. temperature2 mol/L hydrochloric acid under cooling with ice
  3. customThe precipitates produced
  4. filtrationwere filtered
  5. customdried

Sources & evidence

ORD record
ord-422897e9ba88473191cceaa14e9eeb94
Source dataset
uspto-grants-2007_02
Patent number
US07176204B2

Reaction notes

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