Trifluoroacetic acid → HCID 12096111, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product obtained in Example 1 in methanol (100 ml) is added 2M aqueous sodium hydroxide solution (100 ml), and the mixture is stirred at 25° C. overnight. The reaction solution is neutralized with trifluoroacetic acid, and purified by CHP-20 (manufactured by Mitsubishi Chemical Corporation, highporous styrene resin: 75–150 μm) (eluent: gradient, 30% to 100% methanol/0.05% aqueous trifluoroacetic acid solution) to give the title compound (6.5 g).

Provenance & Evidence