Trifluoroacetic acid → HCID 12096111, compound

HRID 347728Notes

Reaction equation

C[O:2][C:3](=[O:39])[C@@H:4]([NH:28][C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:5][NH:6][C:7]([CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]3[NH:23][CH2:24][CH2:25][CH2:26][N:27]=3)[CH:16]=2)[CH2:11][CH2:10]1)=[O:8].[OH-].[Na+].FC(F)(F)C(O)=O>CO>[CH2:32]([O:31][C:29]([NH:28][C@@H:4]([CH2:5][NH:6][C:7]([CH:9]1[CH2:10][CH2:11][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]3[NH:23][CH2:24][CH2:25][CH2:26][N:27]=3)[CH:16]=2)[CH2:13][CH2:14]1)=[O:8])[C:3]([OH:39])=[O:2])=[O:30])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of the product obtained in Example 1 in methanol (100 ml) is added 2M aqueous sodium hydroxide solution (100 ml), and the mixture is stirred at 25° C. overnight. The reaction solution is neutralized with trifluoroacetic acid, and purified by CHP-20 (manufactured by Mitsubishi Chemical Corporation, highporous styrene resin: 75–150 μm) (eluent: gradient, 30% to 100% methanol/0.05% aqueous trifluoroacetic acid solution) to give the title compound (6.5 g).

Workup

custompurified by CHP-20 (manufactured by Mitsubishi Chemical Corporation, highporous styrene resin: 75–150 μm) (eluent: gradient, 30% to 100% methanol/0.05% aqueous trifluoroacetic acid solution)

Sources & evidence

ORD record: ord-8cfcabfe6ddb4865aa27e3909f531cb4
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176199B2

Reaction notes

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