Trifluoroacetic acid → HCID 12096114, compound

HRID 347729Notes

Reaction equation

C[O:2][C:3](=[O:43])[C@@H:4]([NH:32][C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])[CH2:5][NH:6][C:7]([CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]([NH:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[S:23])[CH:16]=2)[CH2:11][CH2:10]1)=[O:8].[OH-].[Na+].FC(F)(F)C(O)=O>CO>[CH2:25]([NH:24][C:22]([NH:21][C:17]1[CH:16]=[C:15]([N:12]2[CH2:11][CH2:10][CH:9]([C:7]([NH:6][CH2:5][C@H:4]([NH:32][C:33]([O:35][CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)=[O:34])[C:3]([OH:43])=[O:2])=[O:8])[CH2:14][CH2:13]2)[CH:20]=[CH:19][CH:18]=1)=[S:23])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of the compound of Example 21 in methanol (2 ml) is added 2M aqueous sodium hydroxide solution (2 ml), and the mixture is stirred at 25° C. overnight. The reaction solution is neutralized with trifluoroacetic acid, and purified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution) to give the title compound (40 mg).

Workup

custompurified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution)

Sources & evidence

ORD record: ord-c7a8901714fc485e8aacf13da460f1c7
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176199B2

Reaction notes

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